Day 1 Istanbul, Turkey

The only city in the world that can lay claim to straddling two continents, Istanbul—once known as Constantinople, capital of the Byzantine and then the Ottoman Empire—has for centuries been a bustling metropolis with one foot in Europe and the other in Asia. Istanbul embraces this enviable position with both a certain chaos and inventiveness, ever evolving as one of the world's most cosmopolitan crossroads. It's often said that Istanbul is the meeting point of East and West, but visitors to this city built over the former capital of two great empires are likely to be just as impressed by the juxtaposition of old and new. Office towers creep up behind historic palaces, women in chic designer outfits pass others wearing long skirts and head coverings, peddlers' pushcarts vie with battered old Fiats and shiny BMWs for dominance of the noisy, narrow streets, and the Grand Bazaar competes with modern shopping malls. At dawn, when the muezzin's call to prayer resounds from ancient minarets, there are inevitably a few hearty revelers still making their way home from nightclubs and bars. Most visitors to this sprawling city of more than 14 million will first set foot in the relatively compact Old City, where the legacy of the Byzantine and Ottoman empires can be seen in monumental works of architecture like the brilliant Aya Sofya and the beautifully proportioned mosques built by the great architect Sinan. Though it would be easy to spend days, if not weeks, exploring the wealth of attractions in the historical peninsula, visitors should make sure also to venture elsewhere in order to experience the vibrancy of contemporary Istanbul. With a lively nightlife propelled by its young population and an exciting arts scene that's increasingly on the international radar—thanks in part to its stint as the European Capital of Culture in 2010—Istanbul is truly a city that never sleeps. It's also a place where visitors will feel welcome: Istanbul may be on the Bosphorus, but at heart it's a Mediterranean city, whose friendly inhabitants are effusively social and eager to share what they love most about it.

Day 3 Rhodes, Greece

Early travelers described Rhodes as a town of two parts: a castle or high town (Collachium) and a lower city. Today Rhodes town—sometimes referred to as Ródos town—is still a city of two parts: the Old Town, a UNESCO World Heritage site that incorporates the high town and lower city, and the modern metropolis, or New Town, spreading away from the walls that encircle the Old Town. The narrow streets of the Old Town are for the most part closed to cars and are lined with Orthodox and Catholic churches, Turkish houses (some of which follow the ancient orthogonal plan), and medieval public buildings with exterior staircases and facades elegantly constructed of well-cut limestone from Lindos. Careful reconstruction in recent years has enhanced the harmonious effect.

Day 4 Heraklion (Iraklion), Crete, Greece

Having been controlled by Arabic, Venetian and Ottoman empires over the years - it's no surprise that Heraklion is a diverse patchwork of exotic cultures and historical treasures. Celebrated as the birthplace of the Spanish Renaissance artist, El Greco, you can visit to explore the storied ruins of the Minoan empire's capital, and unearth the rich cultural treasures that Crete's bustling modern capital has to offer.

Day 6 Messina, Italy

Home to the Museo Regionale of Messina, known for featuring two of Caravaggio's paintings, the city is also famous for having been the capital of the ancient kingdom of Sicily.

Day 7 Amalfi, Italy

At first glance, it's hard to imagine that this resort destination was one of the world's great naval powers, and a sturdy rival of Genoa and Pisa for control of the Mediterranean in the 11th and 12th centuries. Once the seat of the Amalfi Maritime Republic, the town is set in a verdant valley of the Lattari Mountains, with cream-colored and pastel-hued buildings tightly packing a gorge on the Bay of Salerno. The harbor, which once launched the greatest fleet in Italy, now bobs with ferries and blue-and-white fishing boats. The main street, lined with shops and pasticcerie, has replaced a raging mountain torrent, and terraced hills flaunt the green and gold of lemon groves. Bearing testimony to its great trade with Tunis, Tripoli, and Algiers, Amalfi remains honeycombed with Arab-Sicilian cloisters and covered passages. In a way Amalfi has become great again, showing off its medieval glory days with sea pageants, convents-turned-hotels, ancient paper mills, covered streets, and its glimmering cathedral.

Day 8 Civitavecchia, Italy

Italy's vibrant capital lives in the present, but no other city on earth evokes its past so powerfully. For over 2,500 years, emperors, popes, artists, and common citizens have left their mark here. Archaeological remains from ancient Rome, art-stuffed churches, and the treasures of Vatican City vie for your attention, but Rome is also a wonderful place to practice the Italian-perfected il dolce far niente, the sweet art of idleness. Your most memorable experiences may include sitting at a caffè in the Campo de' Fiori or strolling in a beguiling piazza.

Day 9 Livorno, Italy

Livorno is a gritty city with a long and interesting history. In the early Middle Ages it alternately belonged to Pisa and Genoa. In 1421 Florence, seeking access to the sea, bought it. Cosimo I (1519–74) started construction of the harbor in 1571, putting Livorno on the map. After Ferdinando I de' Medici (1549–1609) proclaimed Livorno a free city, it became a haven for people suffering from religious persecution; Roman Catholics from England and Jews and Moors from Spain and Portugal, among others, settled here. The Quattro Mori (Four Moors), also known as the Monument to Ferdinando I, commemorates this. (The statue of Ferdinando I dates from 1595, the bronze Moors by Pietro Tacca from the 1620s.)In the following centuries, and particularly in the 18th, Livorno boomed as a port. In the 19th century the town drew a host of famous Britons passing through on their grand tours. Its prominence continued up to World War II, when it was heavily bombed. Much of the town's architecture, therefore, postdates the war, and it's somewhat difficult to imagine what it might have looked like before. Livorno has recovered from the war, however, as it's become a huge point of departure for container ships, as well as the only spot in Tuscany for cruise ships to dock for the day.Most of Livorno's artistic treasures date from the 17th century and aren't all that interesting unless you dote on obscure baroque artists. Livorno's most famous native artist, Amedeo Modigliani (1884–1920), was of much more recent vintage. Sadly, there's no notable work by him in his hometown.There may not be much in the way of art, but it's still worth strolling around the city. The Mercato Nuovo, which has been around since 1894, sells all sorts of fruits, vegetables, grains, meat, and fish. Outdoor markets nearby are also chock-full of local color. The presence of Camp Darby, an American military base just outside town, accounts for the availability of many American products.If you have time, Livorno is worth a stop for lunch or dinner at the very least.

Day 10 Cannes, France

Cannes is pampered with the luxurious year-round climate that has made it one of the most popular resorts in Europe. Cannes was an important sentinel site for the monks who established themselves on Île St-Honorat in the Middle Ages. Its bay served as nothing more than a fishing port until in 1834 an English aristocrat, Lord Brougham, fell in love with the site during an emergency stopover with a sick daughter. He had a home built here and returned every winter for a sun cure—a ritual quickly picked up by his peers. Between the popularity of Le Train Blue transporting wealthy passengers from Calais, and the introduction in 1936 of France's first paid holidays, Cannes became the destination, a tasteful and expensive breeding ground for the upper-upscale.Cannes has been further glamorized by the ongoing success of its annual film festival, as famous as Hollywood's Academy Awards. About the closest many of us will get to feeling like a film star is a stroll here along La Croisette, the iconic promenade that gracefully curves the wave-washed sand coastline, peppered with chic restaurants and prestigious private beaches. This is precisely the sort of place for which the French invented the verb flâner (to dawdle, saunter): strewn with palm trees and poseurs, its fancy boutiques and status-symbol grand hotels—including the Carlton, the legendary backdrop to Grace Kelly in To Catch a Thief —all vying for the custom of the Louis Vuitton set. This legend is, to many, the heart and soul of the Côte d'Azur. 

Day 11 Barcelona, Spain

The infinite variety of street life, the nooks and crannies of the medieval Barri Gòtic, the ceramic tile and stained glass of Art Nouveau facades, the art and music, the throb of street life, the food (ah, the food!)—one way or another, Barcelona will find a way to get your full attention. The capital of Catalonia is a banquet for the senses, with its beguiling mix of ancient and modern architecture, tempting cafés and markets, and sun-drenched Mediterranean beaches. A stroll along La Rambla and through waterfront Barceloneta, as well as a tour of Gaudí's majestic Sagrada Famíliaand his other unique creations, are part of a visit to Spain's second-largest city. Modern art museums and chic shops call for attention, too. Barcelona's vibe stays lively well into the night, when you can linger over regional wine and cuisine at buzzing tapas bars.

Day 12 Cartagena, Spain

A Mediterranean city and naval station located in the Region of Murcia, southeastern Spain, Cartagena's sheltered bay has attracted sailors for centuries. The Carthaginians founded the city in 223BC and named it Cartago Nova; it later became a prosperous Roman colony, and a Byzantine trading centre. The city has been the main Spanish Mediterranean naval base since the reign of King Philip II, and is still surrounded by walls built during this period. Cartagena's importance grew with the arrival of the Spanish Bourbons in the 18th century, when the Navidad Fortress was constructed to protect the harbour. In recent years, traces of the city's fascinating past have been brought to light: a well-preserved Roman Theatre was discovered in 1988, and this has now been restored and opened to the public. During your free time, you may like to take a mini-cruise around Cartagena's historic harbour: these operate several times a day, take approximately 40 minutes and do not need to be booked in advance. Full details will be available at the port.

Day 13 Motril, Spain

Motril is located in the Spanish region of Andalucia on the Costa Tropical. It is the biggest town on the Costa with a thriving commercial, fishing and leisure port. An hour and a half's drive east of Malaga and within easy reach of the magnificent Sierra Nevada mountain range, Motril makes an ideal base for exploring the many delights of the Andalucian coastline and its hinterland. Halfway between the resorts of Malaga to the west and Almeria to the east, nestling in the foothills of the Sierra Lujar mountains, Motril is at the heart of one of the most fertile and productive agricultural areas of Spain. The Costa Tropical takes its name from its sub-tropical climate which enables the cultivation of exotic fruits and crops such as sugar cane, oranges, lemons, apples, avocadoes, mangoes and bananas. One of the sights of Motril is the 17th-century church of Nuestra Señora de la Cabeza, dedicated to the town's patron saint.

Day 14 Cádiz, Spain

Believed to be the oldest town on the Iberian Peninsula, the Andalusian port of Cádiz enjoys a stunning location at the edge of a six-mile promontory. The town itself, with 3,000 years of history, is characterised by pretty white houses with balconies often adorned with colourful flowers. As you wander around be sure to take a stroll through the sizeable Plaza de Espãna, with its large monument dedicated to the first Spanish constitution, which was signed here in 1812. Cádiz has two pleasant seafront promenades which boast fine views of the Atlantic Ocean, and has a lovely park, the Parque Genoves, located close to the sea with an open-air theatre and attractive palm garden. Also notable is the neo-Classical cathedral, capped by a golden dome.

Day 15 Lisbon, Portugal

Set on seven hills on the banks of the River Tagus, Lisbon has been the capital of Portugal since the 13th century. It is a city famous for its majestic architecture, old wooden trams, Moorish features and more than twenty centuries of history. Following disastrous earthquakes in the 18th century, Lisbon was rebuilt by the Marques de Pombal who created an elegant city with wide boulevards and a great riverfront and square, Praça do Comércio. Today there are distinct modern and ancient sections, combining great shopping with culture and sightseeing in the Old Town, built on the city's terraced hillsides. The distance between the ship and your tour vehicle may vary. This distance is not included in the excursion grades.