Day 1 Ushuaia, Argentina

At 55 degrees latitude south, Ushuaia (pronounced oo-swy-ah) is closer to the South Pole than to Argentina's northern border with Bolivia. It is the capital and tourism base for Tierra del Fuego, the island at the southernmost tip of Argentina.Although its stark physical beauty is striking, Tierra del Fuego's historical allure is based more on its mythical past than on rugged reality. The island was inhabited for 6,000 years by Yámana, Haush, Selk'nam, and Alakaluf Indians. But in 1902 Argentina, eager to populate Patagonia to bolster its territorial claims, moved to initiate an Ushuaian penal colony, establishing the permanent settlement of its most southern territories and, by implication, everything in between.When the prison closed in 1947, Ushuaia had a population of about 3,000, made up mainly of former inmates and prison staff. Today the Indians of Darwin's "missing link" theory are long gone—wiped out by diseases brought by settlers and by indifference to their plight—and the 60,000 residents of Ushuaia are hitching their star to tourism.The city rightly (if perhaps too loudly) promotes itself as the southernmost city in the world (Puerto Williams, a few miles south on the Chilean side of the Beagle Channel, is a small town). You can make your way to the tourism office to get your clichéd, but oh-so-necessary, "Southernmost City in the World" passport stamp. Ushuaia feels like a frontier boomtown, at heart still a rugged, weather-beaten fishing village, but exhibiting the frayed edges of a city that quadrupled in size in the '70s and '80s and just keeps growing. Unpaved portions of Ruta 3, the last stretch of the Pan-American Highway, which connects Alaska to Tierra del Fuego, are finally being paved. The summer months (December through March) draw more than 120,000 visitors, and dozens of cruise ships. The city is trying to extend those visits with events like March's Marathon at the End of the World and by increasing the gamut of winter activities buoyed by the excellent snow conditions.A terrific trail winds through the town up to the Martial Glacier, where a ski lift can help cut down a steep kilometer of your journey. The chaotic and contradictory urban landscape includes a handful of luxury hotels amid the concrete of public housing projects. Scores of "sled houses" (wooden shacks) sit precariously on upright piers, ready for speedy displacement to a different site. But there are also many small, picturesque homes with tiny, carefully tended gardens. Many of the newer homes are built in a Swiss-chalet style, reinforcing the idea that this is a town into which tourism has breathed new life. At the same time, the weather-worn pastel colors that dominate the town's landscape remind you that Ushuaia was once just a tiny fishing village, snuggled at the end of the Earth.As you stand on the banks of the Canal Beagle (Beagle Channel) near Ushuaia, the spirit of the farthest corner of the world takes hold. What stands out is the light: at sundown the landscape is cast in a subdued, sensual tone; everything feels closer, softer, and more human in dimension despite the vastness of the setting. The snowcapped mountains reflect the setting sun back onto a stream rolling into the channel, as nearby peaks echo their image—on a windless day—in the still waters.Above the city rise the last mountains of the Andean Cordillera, and just south and west of Ushuaia they finally vanish into the often-stormy sea. Snow whitens the peaks well into summer. Nature is the principal attraction here, with trekking, fishing, horseback riding, wildlife spotting, and sailing among the most rewarding activities, especially in the Parque Nacional Tierra del Fuego (Tierra del Fuego National Park).

Day 5 Antarctic Peninsula, Antarctica

Remote and otherworldly, Antarctic is irresistible for its spectacular iceberg sculptures and calving glaciers, and for the possibility of up-close encounters with marine mammals and the iconic penguins. The Antarctic Peninsula – the main peninsula closest to South America – has a human history of almost 200 years, with explorers, sealers, whalers, and scientists who have come to work, and eventually intrepid visitors coming to enjoy this pristine and remote wilderness. It is a region of protected bays, unscaled snow-capped mountains, vast glaciers and a few places where whalers or scientists have worked. Just as irresistible are the many Gentoo and Chinstrap Penguin colonies, the seals basking on ice floes, the whales and orcas.

Day 8 South Georgia Island, South Georgia and the South Sandwich Islands

South Georgia is a breathtaking destination of towering snow-covered mountains, mighty glaciers, and low-lying grasslands that attract an astounding concentration of wildlife. It is possible to find Southern fur seals, Southern elephant seals and a variety of albatross species including Black-browed, Light-mantled Sooty, Grey-headed and the spectacular Wandering Albatross, plus thousands of King and Macaroni Penguins. South Georgia is also linked to the early Antarctic explorers. Captain James Cook first stepped ashore in 1775, but perhaps more famous is Ernest Shackleton's arrival in 1916 following the sinking of his ship Endurance. Shackleton's grave and the whaling museum at Grytviken are highlights, as would be a visit to one of the King Penguin colonies at Salisbury Plain or Gold Harbour.

Day 9 South Georgia Island, South Georgia and the South Sandwich Islands

South Georgia is a breathtaking destination of towering snow-covered mountains, mighty glaciers, and low-lying grasslands that attract an astounding concentration of wildlife. It is possible to find Southern fur seals, Southern elephant seals and a variety of albatross species including Black-browed, Light-mantled Sooty, Grey-headed and the spectacular Wandering Albatross, plus thousands of King and Macaroni Penguins. South Georgia is also linked to the early Antarctic explorers. Captain James Cook first stepped ashore in 1775, but perhaps more famous is Ernest Shackleton's arrival in 1916 following the sinking of his ship Endurance. Shackleton's grave and the whaling museum at Grytviken are highlights, as would be a visit to one of the King Penguin colonies at Salisbury Plain or Gold Harbour.

Day 10 South Georgia Island, South Georgia and the South Sandwich Islands

South Georgia is a breathtaking destination of towering snow-covered mountains, mighty glaciers, and low-lying grasslands that attract an astounding concentration of wildlife. It is possible to find Southern fur seals, Southern elephant seals and a variety of albatross species including Black-browed, Light-mantled Sooty, Grey-headed and the spectacular Wandering Albatross, plus thousands of King and Macaroni Penguins. South Georgia is also linked to the early Antarctic explorers. Captain James Cook first stepped ashore in 1775, but perhaps more famous is Ernest Shackleton's arrival in 1916 following the sinking of his ship Endurance. Shackleton's grave and the whaling museum at Grytviken are highlights, as would be a visit to one of the King Penguin colonies at Salisbury Plain or Gold Harbour.

Day 13 Port Stanley, Falkland Islands (Malvinas)

Tiny Stanley, capital of the Falklands, seems in many ways like a British village fallen out of the sky. Many homes are painted in bright colours, adding visual appeal to this distant outpost. Not far offshore, the wreck of the Lady Elizabeth, is one of the many vessels remaining as a silent testimonial to the region's frequent harsh weather conditions.The islands, also known by their Spanish name of Islas Malvinas, are home to arguably more tuxedo-clad inhabitants of the penguin variety than human residents. Various species, such as Gentoo, Magellanic and the more elusive King penguins, either live here permanently or use the Falklands as a stopover on their migration route. Darwin found the islands' flora and fauna fascinating - no doubt you will, too.

Day 16 Puerto Madryn, Argentina

Approaching from Ruta 3, it's hard to believe that the horizon line of buildings perched just beyond the windswept dunes and badlands is the most successful of all coastal Patagonia settlements. But once you get past the outskirts of town and onto the wide coastal road known as the Rambla, the picture begins to change. Ranged along the clear and tranquil Golfo Nuevo are restaurants, cafés, dive shops, and hotels, all busy—but not yet overcrowded—with tourists from around the world.Puerto Madryn is more a base for visiting nearby wildlife-watching sites like Península Valdés and Punta Tombo than a destination in its own right. The town's architecture is unremarkable, and beyond a walk along the coast there isn't much to do. Indeed, even the few museums serve mainly to introduce you to the fauna you'll see elsewhere. The exception is the beginning of whale season (May through July), when the huge animals cavort right in the bay before heading north—you can even walk out alongside them on the pier. During these months it's worth the extra expense for a room with a sea view.The many tour agencies and rental-car companies here make excursion planning easy. Aim to spend most of your time here on one- or two-day trips exploring the surroundings. Note that competition is fierce between tourism operators in destinations such as Puerto Madryn and Puerto Pirámides on Península Valdés. Take information that tour operators and even the tourism office give you about these with a grain of salt: they often exaggerate Madryn's virtues and other areas' flaws.

Day 19 Buenos Aires, Argentina

Glamorous and gritty, Buenos Aires is two cities in one. What makes Argentina's capital so fascinating is its dual heritage—part European, part Latin American. Plaza de Mayo resembles a grand square in Madrid, and the ornate Teatro Colón would not be out of place in Vienna. But you'll know you're in South America by the leather shoes for sale on cobbled streets and impromptu parades of triumphant soccer fans. Limited-production wines, juicy steaks, and ice cream in countless flavors are among the old-world imports the city has perfected.